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Medical Amoxicillin Capsules For Respiratory Infections , Otitis Media And Sinusitis

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Description

AMOXICILLIN?500?MG?Capsules

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COMPOSITION
Each?capsule?contains?amoxycillin?trihydrate?equivalent?to?500?mg?amoxycillin.?

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PHARMACOLOGICAL?ACTION:
Amoxycillin?is?rapidly?absorbed?after?oral?administration?and?provides?high?blood?levels?and?very?high?

concentrations?in?the?tissues?and?urine.?Amoxycillin?does?not?readily?diffuse?into?the?brain?and?spinal

fluid?except?when?the?meninges?are?inflamed.The?ingestion?of?food?does?not?greatly?reduce?the?

absorption?of?amoxycillin.?Amoxycillin?does?not?appear?to?be?metabolized?in?the?body.?Urinary?excretion

?is?rapid,?and?only?unchanged?amoxycillin?is?recovered?in?the?urine.?Its?excretion?can?be?delayed

?by?concurrent?administration?of?probenecid.?Approximately?17%?of?amoxycillin?is?bound?by?serum?

proteins.Amoxycillin?does?not?resist?destruction?by?penicillinase?and?is?thus?not?effective?against

?penicillinase-producing?bacteria,?particularly?resistant?Staphylococci.?All?strains?of?Pseudomonas

?and?most?strains?of?Klebsiella,?indole-positive?Proteus,?Serratia,?Acinetobacter?and?Enterobacter

are?resistant?to?amoxycillin.

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INDICATIONS:
Amoxycillin?is?indicated?in?the?treatment?of?all?infections?caused?by?susceptible?(non-penicillinase?producing)?micro-organisms.
Respiratory?infections?such?as:-
Acute?typical?pneumonia,?acute?and?chronic?bronchitis?and?epiglottitis,?tonsillitis,?pharyngitis,?laryngitis,

?otitis?media,?and?sinusitis.
Urinary?tract?infections?and?uncomplicated?gonococcal?infections.
Bacteraemia,?enteric?fever.
Meningitis?(sensitivity?tests?must?be?performed).
Skin?and?soft?tissue?infections?such?as:-
Pyoderma,?erysipelas,?lymphangitis,?cellulitis.
Gastro-intestinal?infections?such?as:-
Typhoid,?Salmonella?(uncomplicated?gastro-enteritis).
Indicated?surgical?procedures?should?be?performed.

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CONTRA-INDICATIONS:
Patients?hypersensitive?to?penicillins?and?cephalosporins.?Patients?with?infectious?mononucleosis

?are?susceptible?to?skin?rashes.

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WARNINGS:
Amoxycillin?may?cause?reactions?typical?of?penicillin?allergy,?especially?in?sensitive?patients.?Should

an?allergic?reaction?occur,?the?drug?should?be?discontinued?and?the?patient?treated?with?the?usual?

agents.

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DOSAGE?AND?DIRECTIONS?FOR?USE:

The?usual?oral?dose?in?Amoxicillin?250?to?500?mg?every?8?hours.?Children?up?to?10?years?of?age?may

?be?given?125?to?250?mg?every?8?hours;?under?20?kg?body?weight?a?dose?of?20?to?40?mg?per?kg?daily

?has?been?suggested.



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SIDE?EFFECTS?AND?SPECIAL?PRECAUTIONS:

Side-effects:

Adverse?events?associated?with?amoxycillin?are?allergic?reactions?which?commonly?include?urticarial?

or?maculopapular?skin?rashes.
Amoxycillin?may?cause?reactions?typical?of?penicillin?allergy?in?patients?sensitive?to?penicillin.?

Gastro-intestinal?adverse?effects?particularly?diarrhoea?and?also?nausea?and?vomiting?occur?quite?frequently,?

usually?following?administration?by?mouth.?Glossitis,?stomatitis?and?black-& quot;hairy& quot;?tongue?have?been?reported.?Pseudomembranous?colitis?has?also?been?reported.?Supra-infections?with?non-susceptible?organisms?may?occur?particularly?with?prolonged?use.

Precautions:

Amoxycillin?should?not?be?given?to?patients?with?infectious?mononucleosis,?lymphatic?leukaemia?and

?patients?with?hyperuricaemia?being?treated?with?allopurinol,?since?these?patients?appear?to?have?a

?higher?incidence?of?skin?rashes.
Anaemia,?thrombocytopenia,?thrombocytopenic?purpura,?eosinophilia,?leukopenia?and?agranulocytosis?

have?been?reported?during?therapy?with?the?penicillins.?These?reactions?are?usually?reversible?on?

discontinuation?of?therapy?and?are?believed?to?be?hypersensitivity?phenomena.

Amoxycillin?may?decrease?the?efficacy?of?oestrogen-containing?oral?contraceptives?and?it?may?also?

affect?the?absorption?of?other?drugs?due?to?its?effect?on?the?gastro-intestinal?flora.Safety?of?use?

during?pregnancy?has?not?been?established.


STORAGE?INSTRUCTIONS:
Store?below?25°C.?Protect?from?moisture.
The?potency?of?reconstituted?suspensions?will?be?maintained?for?one?week?at?temperatures?not?

exceeding?25°C?and?for?two?weeks?under?refrigeration(2°C–8°C).
KEEP?OUT?OF?REACH?OF?CHILDREN.

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