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Orotic acid CAS 65-86-1 Pyrimidinecarboxylic Acid (jerryzhang001@chembj.com)

65-86-1

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Description

Orotic acid CAS 65-86-1 Pyrimidinecarboxylic Acid

Product Name: Orotic acid;
Synonyms: 1,2,3,6-tetrahydro-2,6-dioxo-4-pyrimidecarboxylicacid[qr];1,2,3,6-tetrahydro-2,6-dioxo-4-pyrimidinecarboxylicaci;2,6-Dihydroxy-4-pyrimidinecarboxylic acid;4-Pyrimidinecarboxylic acid, 1,2,3,6-tetrahydro-2,6-dioxo-;4-pyrimidinecarboxylicacid,1,2,3,6-tetrahydro-2,6-dioxo-[qr];6-carboxyuracil[qr];acideorotique(french)[qr];acidoorotico;
CAS: 65-86-1;
MF: C5H4N2O4;
MW: 156.1;
EINECS: 200-619-8;

Product Categories: Vitamin Ingredients;Daily-use cosmetics and medicine nucleic acid biological research;Inhibitors;pharmaceutical;

Melting point: >300°C;
Water Solubility: Slightly soluble;

Chemical Properties: It appears as white crystalline powder with the melting point being 345-346 ℃ (decomposition).

Description:

1. Orotic acid is useful in delineating the cause of hyperammonemia.Excessive amounts of orotic acid are usually found in OTC (ornithine transcarbamylase) deficiency, citrullinemia, and often in argininosuccinic aciduria.
2. Orotic acid is a heterocyclic compound and an acid. It was once believed to be part of the vitamin B complex and was called vitamin B13, but it is now known that it is not a vitamin but is instead manufactured in the body by intestinal flora. Its salts, known as orotates, are sometimes used as mineral carriers in some dietary supplements, to increase their bioavailability.
3. It is an intermediate in de novo pyrimidine biosynthesis that may be used to study the specificity and kinetics of orotate phosphoribosyltransferase (OPRT) which catalyzes the reversible phosphoribosyl transfer from 5′-phospho-α-d-ribose 1′-diphosphate (PRPP) to orotic acid, forming pyrophosphate and orotidine 5′-monophosphate (OMP). It may be used to study dependent cell signaling pathways and transcription regulation mechanisms that induce hepatic lipogenesis.

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