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Galanthamine Hydrobromide

1953-04-4

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Description

Original Plant：Shorttube Lycoris

Specification：99%

Synonym(s) ：Reminyl, Nivalin

Chemical Name：(4aS,6R,8aS)-6-Hydroxy-3-methoxy-11-methyl-5,6,9,10,11,12-hexahydro-4aH-benzofuro[3a,3,2-e,f][2]benzazepine hydrobromide

Test Method：HPLC

Molecular Formula：C17H21NO3.HBr;C17H22BrNO3

Molecular Weight：368.27

CAS No.： 1953-04-4

EINECS No.: 217-780-5
Melting Point : 258~264 ℃
Solubility: Soluble in water,and slightly in alcohol.
Appearance: White to whitish crystal powder, oderless and tasteless.
Pharmacology Action: Galanthamine extract is specific, competitive and reversible acetylcholinesterase inhibitor. It is also an allosteric modulator at nicotinic cholinergic receptor sites potentiating cholinergic nicotinic neurotransmission. Both the acetylcholine and nicotine receptors have been suggested as areas related to cognitive impairment. Initially, Galanthamine extract was used in anesthesiology to antagonize the effects of non-depolarizing muscle relaxants, and since then it was rapidly introduced in other areas of medicine, i.e. neurology, ophthalmology, gastroenterology, intensive care and resuscitation, cardiology, physiotherapy.
Galanthamine extract is a product with broad therapeutic index, allowing & quot;soft& quot; manifestation of its effect with individual dosing depending on the particular case.
Several trials already showed that Galantamine 16 and 24 mg/day significantly benefits the cognitive, functional, and behavioral symptoms of AD as compared with placebo and proved also to be very effective in symptomatic treatment of senile dementia of Alzheimer& acute;s type.

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