Organic Chemicals
Description
Name 4-Hydroxy-D-phenylglycine
Synonyms 4-Hydroxy-D-(-)-2-phenylglycine; D-(-)-p-Hydroxyl Phenylglycine; (2R)-2-Amino-2-(4-hydroxyphenyl)acetic acid; H-D-Phg(4-OH)-OH; D(-)-4-Hydroxyphenylglycine; D-HPG; D-PHPG; (R)-a-Amino-4-hydroxyphenylacetic acid
Molecular formula C8H9NO3
Molecular weight 167.16
CAS No. 22818-40-2
Purity 99%
Water content ≤0.5%
Apparence White or off-white crystalline flake or powder
Solubility Slightly soluble in ethanol and water; soluble in acid or alkali solution and generate salt.
Package 25kg/drum
What is 4-Hydroxy-D-phenylglycine?
4-Hydroxy-D-phenylglycine,also known as D-P-Hydroxyphenylglycine, (2R)-2-Amino-2-(4-hydroxyphenyl)acetic acid and D-(-)-p-Hydroxyl Phenylglycine, is an important pharmaceutical intermediate. It is a side-chain chemical compound for the synthesis of semisynthetic penicillin and semisynthetic cephalosporins, including beta-lactam semisynthetic antibiotics such as amoxicillin, amoxicillin clavulanic acid salt, cefaclox, cefadroxil, amoxicillin with ceftazidime, cefoperazone, cefatrizine, and so on.
The antimicrobial spectrum of the antibiotics synthesized from 4-Hydroxy-D-phenylglycine is quite broad. They are active against both gram-positive bacteria and gram-negative bacteria. As a new generation, the antibiotics are very effective when taken orally. They also have eliminated the defects of narrow antimicrobial spectrum, side effects, poor acid resistance, incapability of being taken orally or ineffective when taken orally, and drug tolerance specified by penicillin G. As a result, they are more and more popular in clinic application, and the need for 4-Hydroxy-D-phenylglycine has been expanding.
In the meantime, 4-Hydroxy-D-phenylglycine is also applied in the photosensitive field and as the analytical reagent for iron, phosphorus, and silicon. It is also a key intermediate for the synthesis of artificial sweeteners.
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Banff Green Technologies, Inc.
diethyl fluoromalonate, dimethyl fluoromalonate, d-p-methyl sulfone phenyl ethyl serinate, florfenicol, d-(-)-threo-2-amino-1-(4-nitrophenyl)-1,3-propanediol, chloramphenicol
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